The Semi-Gods Ceiling is a painting work by Italian Renaissance master Pinturicchio, dating to c. 1490 and housed in the right wing hall of the Palazzo dei Penitenzieri in Rome, Italy. It comprises 63 octagonal coffers in gilt wood, decorated with allegoric and mythological figures on a fake mosaic background, and painted on paper.

The work was commissioned by Cardinal Domenico della Rovere, at the time patron of the young Pinturicchio.

The figures of the ceiling were inspired by medieval bestiaries and libri monstruorum, which contained hybrid figures such as sphinxes, armed tritons, satyrs, dragons, sirens and centaurs. The theme has hidden philosophical and humanist meanings, perhaps suggested by the literates which formed the cardinal's court.

In the center is the genealogical tree of the Della Rovere with two peacocks, which can be seen also at the corners. One of the representation is a nude allegory of Fortune, which rides a dolphin, differently from the contemporary Florentine depictions in which she is portrayed on a small boat. There is also a putto on two sea horses going to different directions, a Neoplatonic allegory of the human soul, divided between the Good and Evil, according to Marsilio Ficino's 1475 comments to Plato's Symposium. The Weighing of the Soul and the Eagle Defeating the Snake are ancient themes which had been syncretized by the Christian world.

Numerous depictions are of sea creatures, including sirens with two tails, painted while milking, leading pups, painting or executing acrobatic dances. They were perhaps an element inspired by the sea thiasus featured in Roman sarcophagi, and which was also used by Andrea Mantegna, whom perhaps Pinturicchio met in the building of the Belvedere Palace in the Vatican.

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